子宫腺肌病组织中血小板源性生长因子及信号传导与转录激活因子3的表达及意义

Expression of PGDF and STAT3 in adenomyosis

目的探讨血小板源性生长因子(platelet-derived growth factor,PDGF)和信号传导与转录激活因子3(signal transducers and activators of transcription,STAT3)在子宫腺肌病在位及异位内膜组织中的表达情况及其对发病的作用。方法 2006年1月至2009年8月在山西医科大学第一临床医学院应用组织芯片和免疫组化法,检测子宫腺肌病(研究组)和对照组(正常子宫内膜)子宫内膜组织中PDGF、STAT3的表达情况,采用SPSS13.0统计软件包进行数据分析,比较两者之间的差异。结果研究组中,PDGF在位子宫内膜及异位内膜的阳性表达率(47.14%,54.29%),均显著高于对照组(12.50%),P<0.05;STAT3在位子宫内膜及异位内膜的阳性表达率(65.71%,61.43%),均显著高于对照组(29.17%),P<0.05。两者在异位内膜组织中的表达呈正相关关系(r=0.274)。结论子宫腺肌病内膜组织中PDGF、STAT3高表达,可能与子宫腺肌病的发生、发展有关。

Objective To investigate the expression of platelet-derived growth factor （PDGF）and STAT3 in adenomyosis eutopic and ectopic endometrial tissues and their effect in adenomyosis, in order to investigate the possible molecular mechanism of the pathopoiesis of adenomyosis and provide the oretical evidence that contributes to uncover the new molec- ular targets of the diagnosis and treatment of adenomyosis. Methods Between January 2006 and August 2009 in the First Clinical Medical College of Shanxi Medical University. Tissue microarray and immunohistochemistry methods were employeed to study the expression of PDGF and STAT3 in adenomyosis specimens and CIN IU （ normal endometrium ） specimens. All data were processed by SPSS version 13. 0 analysis software. Results The expression of PDGF and STAT3 was sign-ificantly higher in eutopic and ectopic endometrium of adenomyosis than normal endometrium （P 〈 0. 05 ）. The expression of PDGF and STAT3 in ectopic endometrium of adenomyosis was correlated （ r = 0. 274 ）. Conclusion The expression of PDGF and STAT3 were higher in the endometrium of adenomyosis samples than normal endometrium, which suggested that PDGF and STAT3 are closely related to the pathopoiesis of human adenomyosis.