射干麻黄地龙散对鸡肝肾功能及脏器剖检的影响

Effects of Shegan Mahuang Dilong Powder on the Kidney and Liver Functions and the Pathological Examination in Chickens

本试验旨在了解射干麻黄地龙散的安全性,为临床用药提供数据支持。选取120只21日龄三黄肉鸡,随机分为3倍剂量组、6倍剂量组、12倍剂量组和对照组,每组30只。在21和35日龄时分别按试验鸡的平均体重给予不同剂量的药物,并连续饲喂2周。在35和49日龄时,各组随机选取10只进行采血和剖检。测定肝肾功能指标,同时对剖检鸡的心脏、肝脏、脾脏、肺脏和肾脏进行病理检查。结果显示,各组鸡的血清丙氨酸氨基转移酶活性及肌酐含量与药物剂量间无规律性变化,白蛋白含量和尿素含量与对照组差异不显著(P>0.05)。用药后,各组鸡的心脏、肝脏、脾脏、肺脏和肾脏均无明显差异,表现正常。结果表明,射干麻黄地龙散对鸡肝肾功能的影响小,病理剖检未见对心脏、肝脏、脾脏、肺脏和肾脏产生毒性作用,是一种适合临床应用的低毒、安全的中药制剂。

In order to make clear the safety of Shegan Mahuang Dilong powder and provide date support for the clinical medication,120 21-day-old Sanhuang broilers were randomly divided into four groups including 3,6,12 times dose group and control group,every group had thirty broilers.When the chickens were 21 and 35 days old,according to the chickens＇ average weight of each group,the drug of different doses was fed to the chicken and the drug was fed for 2 weeks continuously.When the chickens were 35 and 49 days old,10 chickens in each group were randomly selected for blood collection and necropsy.Then the parameters of kidney and liver functions were measured and the pathological examination of hearts,livers,spleens,lungs and kidneys was carried out.The results showed that there was no regularity between the serum alanine aminotransferase activity,creatinine concentration and drug＇s dosages of each group while the levels of albumin and urea had no significant differences compared with the control group（P〉0.05）.After administration,the chickens＇ hearts,livers,spleens,lungs and kidneys were no significant differences in the performance of normal in all groups.The results showed that Shegan Mahuang Dilong powder had small interference to kidney and liver functions of the chickens.And there were no toxic effects to the heart,liver,spleen,lungs and kidney after pathological examination.So it was a low toxic and safe traditional Chinese medicine preparation which was suitable for clinical use.