摘要
对猪血红蛋白作为血液替代品的效果进行研究,提取猪血红蛋白,经PEG聚合及纯化,输给试验犬,检测、记录犬输入聚合血红蛋白前后的临床指标,并在输血后进行血常规和尿常规检测。结果表明,将聚合猪血红蛋白输入犬体内没有发生明显的溶血和凝血等输血反应,通过尿常规检测聚合血红蛋白在体内可存在7 d;第2次聚合血红蛋白输血也没有出现临床不良反应。结果显示聚合血红蛋白作为血液替代品有较好的临床应用前景。
The objective of this paper was to study the effect of the pig hemoglobin as substitute.The hemoglobin was extracted from the pig＇s blood and polymerized by PEG and purified by centrifuged,then transferred to dogs.Both the clinical indicators and blood and urine index were detected continuously before and after transfusion.The dog hadn＇t occurred coagulation and hemolytic reaction.It showed that hemoglobin polymerization could exist in the dog＇s blood for 7 days by detecting urine.There were no adverse clinical reactions occur after second transfusion.The polymerization of hemoglobin will be better prospects for clinical application in blood substitutes.
出处
《中国畜牧兽医》
CAS
北大核心
2010年第9期223-225,共3页
China Animal Husbandry & Veterinary Medicine
基金
湖南省第一批大学生研究性学习和创新性实验计划项目
湖南农业大学大学生创新性实验计划项目(YCX1019和60030183705)
关键词
聚合猪血红蛋白
犬
异源输血
血液替代品
polymerized hemoglobin
dog
heterologous transfusion
blood substitute
