肝细胞性肝癌复发再手术切除的疗效分析

Analysis of Efficacy of Hepatocellular Carcinoma Recrrence Reoperation

目的探讨肝细胞性肝癌复发(HCC)再手术切除治疗的意义。方法回顾性分析2000-2007年间45例HCC复发后再手术切除的临床资料。结果再手术切除的1、3、5年累积生存率分别为93.3%、60.0%、17.7%。第2次手术后1、3、5年的生存率分别为81.1%、46.1%、11.3%。病人的生存时间与年龄、性别、血清AFP水平无关(P>0.05),与肿瘤的大小、多少及血管侵犯有关(P<0.05)。结论再手术切除治疗可以改善病人的生活质量,延长病人的生存时间。肿瘤的大小、多少、血管侵犯是影响HCC预后和复发的重要因素。

Objective To evaluate the clinical significance of the reexcision for recurrent hepatocellular carcinoma（HCC）.Methods The clinical data of 45 cases of recurrent HCC from 2000 to 2007 were analysed retrospectively.Results The accumulated one-year,three-year and five-year survival rate were 93.3%,60.0% and 17.7% for the HCC patients received reexcision,and the one-year,three-year and five-year survival rate after secondary excision were 81.1%、46.1%、11.3%,respectively.The survival time correlated with not age,sex and serum AFP level（P0.05）,but the tumor size,number and vascular invasion（P0.05）.Conclusion The reexcision intervention for HCC patients can improve life quality,prolong survival time.Tumor size,number and vascular invasion are important for the prognosis and recurrence of HCC.