抗结核药物性肝损临床治疗观察

Clinical Treatment Observation of Anti-tuberculosis Drug-induced Liver Damage

目的探讨抗结核药所致肝功能损害的临床治疗方法。方法将抗结核药物性肝损患者88例随机分为治疗组和对照组各44例:对照组给予门冬氨酸钾镁等治疗;治疗组予以甘草酸二胺加还原型谷胱甘肽治疗。2周后观察两组治疗前后患者的临床症状、体征和肝功能等变化情况。结果治疗组和对照组总有效率分别为95.5%和72.7%,治疗组疗效优于对照组,差异有显著性(P<0.05)。两组治疗前后肝功能明显改善,组间比较,差异有显著性(P<0.01)。治疗后治疗组的肝功能恢复情况明显优于对照组(P<0.05)。结论甘草酸二铵联合还原型谷胱甘肽治疗抗结核药物性肝损疗效确切,安全可靠。

Objective To explore clinical treatment of liver damage caused by anti-tuberculosis drugs.Methods Totally 88 cases of anti-tuberculosis drug-induced liver damage patients were randomly divided into the treatment group of 44 cases and the control group of 44 cases.The control group used potassium magnesium aspartate.The treatment group used diammonium glycyrrhizinate combined with reduced glutathione.To observe the change of clinical symptoms and signs and liver function before and after the treatment after 2 weeks.Results The total effective rates in treatment group and control group were respectively 95.5% and 72.7%,the effect of the treatment group was better than that of the control group,there was a significant difference（P0.05）.There was significant changes in the liver function of the two groups before and after the treatment,there was significant difference in the comparison between the two groups（P0.01）.Liver function recovery of the treatment group after the treatment was better than the control group（P0.05）.Conclusion Diammonium glycyrrhizinate combined with reduced glutathione in the treatment of anti-tuberculosis drug-induced liver damage has exactly curative effect,safe and reliable.