T细胞在多发性硬化发病机制中作用的研究进展

T cells in the pathogenesis of multiple Sclerosis

多发性硬化（MS）是临床常见的炎性、脱髓鞘性中枢神经系统（CNS）退行性变,通常认为是T细胞介导的自身免疫性疾病,但其具体病因和发病机制尚不清楚.近年来研究表明,多个亚型的T细胞均参与了MS的发病及其病程的调控.其中包括CD4^＋Th1细胞、CD8^＋T细胞、Th17细胞、CD16＋γδ T细胞、Th2细胞、调节性CD4＋T细胞、NK T细胞、CD8＋调节性T细胞等,因而研究MS了发病机制具有重要意义.

Multiple sclerosis （MS） is an inflammatory, demyelinating, neurodegenerative disorder of the central nervous system （CNS） of unknown etiology. It is generally believed that it is a T cell-mediated autoimmune disease. Recent researches have revealed the involvement of various types of T cell that mediates the pathogenesis and progress of MS including CD4＋ autoreactive Th1 cells, CD8 ＋ autoreactive T cells, Th17 cells, CD16＋ γδ T cells, Th2 cells, NK T cells, CD4^＋ or CD8^＋ regulatory T cells. The molecular mechanisms underlying the effects of these T cells remain to be studied.