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Th9细胞与自身免疫性疾病 被引量：3

Th9 cells and autoimmune diseases
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摘要 Th1、Th2、Th17和调节性T细胞（Treg）亚群是CD4＋T细胞亚群中的重要成员,其参与了人类及动物自身免疫性疾病的发病过程.既往认为,IL-9是由CD4＋Th2细胞分泌的细胞因子,是机体免疫应答中重要的调节因子.最近研究表明,机体内可能存在着一群新型的具有分泌IL-9和IL-10能力的CD4＋Th细胞亚群,称之为＂Th9＂细胞.该细胞亚群与自身免疫性疾病的相关性尚不清楚. T helper type 1 （ Th1 ）, Th2, Th1 7 and the Treg are important members of Helper CD4^ ＋ T-cell, which participate in the pathogenesis of autoimmune diseases in humans and animal models. IL-9 was primarily recognized as a product of CD4^ ＋ Th2 cells and an important regulatory cytokine in immunologic responses. Recent data suggest that a distinct population of IL-9 and IL-10 producing helper CD4^＋ T-cells, named Th9, may exist. The role of Th9 cells in autoimmune diseases is currently unknown.
作者 杨帆 伍伟锋
机构地区 广西医科大学第四附属医院心内科
出处 《国际免疫学杂志》 CAS 北大核心 2010年第5期350-353,共4页 International Journal of Immunology
基金 国家自然科学基金资助项目（30960129）
关键词 TH9细胞 自身免疫性疾病 Th9 Autoimmune diseases
分类号 R593.2 [医药卫生—内科学]
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参考文献20

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共引文献9

同被引文献38

  • 1Veldhoen M,Uyttenhove C,van Snick J,et al.Transforming growth factor-beta'reprograms'the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset[J].Nat Immunol,2008,9(12):1341-1346.
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引证文献3

二级引证文献19

国际免疫学杂志
2010年 第5期

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