霍乱毒素佐剂应用研究进展

Cholera toxin as potent immuno-adjuvant

霍乱毒素（CT）是霍乱弧菌分泌的一种不耐热肠毒素，具有很强的免疫原性和佐剂活性。CT本身有很强的毒副作用，如何既能具备优良的佐剂活性而又没有明显的毒副作用是当前研究的主要目标。CT及其亚单位因其独特的生理功能已被广泛地应用到很多新的免疫与疫苗策略中，已成为当前重要的佐剂之一。

Cholera toxin （CT） is a cholera-secreted, heat-labile enterotoxin with potent adjuvant and immunomodulatory activities. It has been well studied as a mucosal immunity adjuvant. It seems that the adju- vant efffect of CT is tightly associated with its toxicity. How to balance its adjuvant activity and toxicity becomes the major concern in the recent studies. The unique advantage of both CT and its subunits has been extensively employed in new vaccine development strategy.