促炎性与抗炎性细胞因子在重症肌无力发病机理及诊断治疗中的作用研究进展

Research progress on pro-inflammatory and anti-inflammatory cytokines in the pathogenesis, diagnosis and therapy of myasthenia gravis

重症肌无力（MG）是一种抗体介导,T细胞免疫依赖性、补体参与的自身免疫性疾病.国内外众多研究者通过自身免疫性MG动物模型（EAMG）或检测MG病人的某些指标证明了多种细胞因子通过复杂的机制参与到MG发病过程.其中一些细胞因子能促进发病,而另一些则抑制发病.这些研究结果可能会有助于找到治疗MG的新方法.大部分细胞因子的具体作用机理尚需进一步研究论证.

Myasthenia gravis （MG） is antibody-mediated, T-cell dependent and complement involved autoimmune disorders. From the studies on MG patients and animal model, it was found that a variety of cytokines involved in the pathogenesis of MG through a complex mechanism. Some of these cytokines can promote the pathogenesis of the disease, while others play the opposite role. These findings may help to find new ways for the treatment of MG. However the specific role of most of these cytokines in the pathogenesis of MG need to be further studied.