mTOR抑制剂-雷帕霉素对树突状细胞功能调控的研究进展

Research advances in the study of the regulatory effect of mTOR inhibitor-rapamycin on dendritic cells

哺乳动物雷帕霉素靶蛋白（mTOR）作为信号通路的调节器能形成细胞对各种刺激的应答,而雷帕霉素则是通过阻断mTOR参与的信号转导阻止DC的功能从而发挥其免疫抑制作用.免疫细胞能通过表面受体直接或间接地向mTOR传导信号,调节免疫应答.研究表明：mTOR可调控不同种类的抗原提呈细胞（APC）,如树突状细胞（DC）的分化与成熟、存活、迁移、抗原摄取与应答以及细胞因子产生等,对固有免疫和适应性免疫都有重要的调节作用.

The mammalian target of rapamycin （mTOR） in innate and adaptive immune responses is becoming apparent. mTOR regulates diverse functions of dendritic cells （DCs）, such as DC differentiation,maturation, survival, migration, antigen uptake and presentation, and cytokine production. The immunosuppressive effect of rapamycin is achieved by inhibiting mTOR and impairing the maturation and functions of DC.