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MR-T1ρ成像的基本原理及临床应用 被引量：5

The Basic theories and clinical applications of T1ρ-MRI
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摘要 MR-T1ρ成像是近年出现的一种最新MRI技术,T1ρ弛豫主要反映水分子与周围大分子之间相互作用引起的弛豫.因其视角独特,被尝试用于活体探查病变早期的多种病理机制,如关节软骨中的胶原蛋白含量、神经退行性疾病的神经元凋亡等,为超早期显示病变及判断治疗效果提供了新的工具. MR-T1ρ imaging is one of the novelest MRI techniques in recent years,T1ρ relaxation mainly reflect the interaction between water molecules and the surrounding macromolecu]es.Due to the unique point of view,the technique has been used to investigate a variety of pathological mechanisms in early stage of diseases,such as the content of collagen protein in articular cartilage,neuron apoptosis in neurodegenerative diseases and so on,which provides a new tool for detecting lesions in ultra-early stage or the evaluation of treatment effect.
作者 武柏林 刘怀军
机构地区 河北医科大学第二医院医学影像科
出处 《国际生物医学工程杂志》 CAS 北大核心 2010年第4期249-253,I0001,共6页 International Journal of Biomedical Engineering
关键词 磁共振成像 T1ρ弛豫 软骨 神经退行性疾病 MRI T1ρ relaxation Cartilage Neurodegenerative diseases
分类号 R445.2 [医药卫生—影像医学与核医学]
  • 相关文献

参考文献44

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二级参考文献15

  • 1康宁,俎栋林,张宏杰.自旋密度ρ、弛豫时间T1和T2定量磁共振成像[J].中国医学影像技术,2004,20(12):1944-1947. 被引量：16
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共引文献5

同被引文献49

  • 1朱天缘,刘斯润,林志超,陈汉芳.正常成人膝关节软骨MR扩散加权成像[J].暨南大学学报（自然科学与医学版）,2006,27(2):309-311. 被引量：2
  • 2汤敏生,彭伟雄,江笑娥,梁惠萍,何剑鸿,钟志刚,简振尧,彭荣春,黄伟钢,孟丽红,张景辉.广州市荔湾区社区居民症状性骨关节炎患病情况调查[J].广东医学,2007,28(9):1506-1509. 被引量：25
  • 3沈思,刘斯润,朱天缘,梁文彬,黄力,陈汉芳,吴何嘉.钆对比剂增强及延迟增强MR扫描监测兔膝关节软骨退变的研究[J].中华放射学杂志,2007,41(12):1394-1400. 被引量：13
  • 4Makela HI, Grohn OH, Kettunen MI, et al. Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions. Biochem Biophys Res Commun, 2001, 289(4): 813-818.
  • 5Li X, Benjamin Ma C, Link TM, et al. In vivo T1ρ and T2 mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI. Osteoarthritis Cartilage, 2007, 15(7): 789-797.
  • 6Blumenkrantz G, Li X, Han ET, et al. A feasibility study of in vivo T1rho imaging of the intervertebral disc. Magn Reson Imaging, 2006, 24(8): 1001-1007.
  • 7Johannessen W, Auerbach JD, Wheaton AJ,et al. Assessment of human disc degeneration and proteoglycan content using T1ρ weighted magnetic resonance imaging. Spine (Phila Pa 1976), 2006, 31(11): 1253-1257.
  • 8Poptani H, Duvvuri U, Miller CG, et al. T1rho imagine of murine brain tumors at 4 T. Acad Radiol, 2001, 8(1): 42-47.
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引证文献5

二级引证文献21

国际生物医学工程杂志
2010年 第4期

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