甘草酸二铵磷脂复合物注射液与4种常用输液配伍的稳定性考察

Investigation of the Compatible Stability of Diammonium Glycyrrhizinate Phospholipid Complex Injection in Four Infusions

目的:在25℃、4℃条件下考察甘草酸二铵磷脂复合物注射液与4种常用输液配伍的稳定性。方法:采用高效液相色谱法测定甘草酸二铵磷脂复合物注射液在4种常用输液中24h内的含量变化,同时观察外观,测定pH变化。结果:甘草酸二铵磷脂复合物注射液与5%葡萄糖氯化钠注射液配伍中出现浑浊,与5%葡萄糖注射液、10%葡萄糖注射液、0.9%氯化钠注射液配伍中,外观、pH值、含量无显著变化。结论:试验结果表明甘草酸二铵磷脂复合物注射液不宜与5%葡萄糖氯化钠注射液配伍使用,与其他3种常用输液配伍稳定。

Objective：To study the compatible stability of diammonium glycyrrhizinate phospholipid complex injection（DGPC） in four infusions at 25℃ and 4℃.Methods： The contents of DGPC injection in four mixed solutions within 24 hours were determinated by HPLC,and the appearance and pH value of the mixed solutions were also examined. Result： No significant change was found in appearance、pH and content of DGPC injection after it was mixed with three infusions（0.9% NaCl solution, 5% glucose injection, and 10% glucose injection）. Conclusion： DGPC injection was stable when mixed with three injections（0.9% NaCl solution, 5% glucose injection, and 10% glucose injection ） and was unstable in the 5% glucose and NaCl solution.