90例甲硝唑缓释药膜治疗牙周炎的疗效观察

Metronidazole Release Membrane for Periodontitis:Treatment Efficacy of 90 Cases

目的探讨应用甲硝唑缓释药膜治疗牙周炎的临床疗效。方法选择我院口腔门诊2008年1月～2009年12月收治的牙周炎患者180例作为研究对象,全部患者按照入院先后顺序随机分为治疗组和对照组各90例,其中治疗组放置甲硝唑缓释药膜,对照组给予碘甘油灌注20g/L,观察比较两组的牙龈指数(GI)、牙周袋探诊深度(PD)的变化及疗效情况。结果治疗组的总有效率为97.8%,明显高于对照组的总有效率(72.2%),两组总有效率比较,差异有统计学意义(P<0.05)。治疗前两组GI、PD差异无显著性,治疗后,两组GI、PD分别与治疗前比较明显减小,差异有显著性(tGI=2.467,tPD=2.643,P<0.05)。且治疗组与对照组GI、PD分别比较,治疗组GI和PD指数明显低于对照组,差异有显著性(tGI=2.575,tPD=2.732,P<0.05)。结论甲硝唑缓释药膜具有可吸收性,释放缓慢,牙周袋内药物浓度高,维持时间长,疗效好,值得临床广泛推广和应用。

Objective To evaluate the efficacy of metronidazole slow-release membrane in the treatment of periodontitis. Methods We selected 180 cases of periodontitis treated in our hospital dental clinic from Jan. 2008 to Dec. 2009 and all cases were divided randomly into treatment group and control group. The treatment group was treated by placing metronidazole release membrane and the control group received iodine glycerin infusion, 20g/L, and the gingival index （GI） of two groups, the periodontal probing depth（PD） and the efficacy were observed and compared. Results The total effective rate of the treatment group was 97.8%, significantly higher than that of the control group（72.2%）, with a significant difference, P〈0.05. There was no significant difference in GI and PD between the two groups before treatment, but a significant difference after treatment（tCI= 2.467, tPD =2.643, P〈0.05）. Conclusion Metronidazole is a absorbable slow-release membrane, resulting in high concentration in PD , long time maintenance and better effect, worthy of wide dissemination and application.