蓝光联合大黄液直肠给药治疗重症新生儿黄疸的临床研究

Blu-ray Combined with Rhubarb Liquid in Treatment of Severe Neonatal Hyperbilirubinemia

目的观察蓝光联用大黄液直肠给药治疗重症新生儿高胆红素血症的效果。方法将78例重症新生儿高胆红素血症患者随机分为对照组和观察组,对照组采用蓝光加常规治疗,观察组在此基础上联用大黄液直肠给药治疗,随后对两组患者的临床效果进行比较。结果观察组和对照组治疗前血清总胆红素(TBiL)和未结合胆红素(IBiL)差异无统计学意义(P>0.05),但治疗后观察组TBiL为(124.30±24.70)μmol/L,明显低于对照组(156.40±29.60)μmol/L,差异具有统计学意义(P<0.01);治疗后观察组IBiL为(89.10±11.30)μmol/L,明显低于对照组(98.50±12.60)μmol/L,差异具有统计学意义(P<0.05)。观察组在治疗后1～3d黄疸消退,对照组在治疗后5～7d黄疸消退。治疗期间两组均未见不良反应。结论蓝光联合大黄液直肠给药治疗重症新生儿高胆红素血症疗效显著,适合临床推广。

Objective To observe the effects of Blue-ray combined with rhubarb liquid in the treatment of severe neonatal hyperbilirubinemia. Methods Seventy-eight cases of severe neonatal hyperbilirubinemia were randomly divided into control group and observation group. The control group was given Blue-ray therapy and conventional treatment, and rhubarb liquid was added to the observation group on the basis of the control group. The clinical effects were compared between the two groups. Results There was no significant difference of TBiL or IBiL between the observation group and control group before treatment（ P〉0.05 ）, but after treatment TBiL of observation group was（ 124.30 ± 24.70） μ mol/L, significantly lower than that of the control group （ 156.40 ± 29.60） μmol/L （P〈 0.01 ）, and IBiL was （89.10 ± 11.30 ） μ mol/L, significantly lower than that of the control group（98.50 ±12.60） μ mol/L（P〈0.05 ）. Jaundice disappeared after 1-3 days in the observation group,and after 5-7 days in the control group. There were no adverse reactions during the treatment period in the two groups. Conclusion The Blue-ray combined rhubarb liquid in the treatment of neonatal hyperbilirubinemia has significant effects, worthy of promotion.