胆汁癌胚抗原诊断胆系良恶性病变的探讨

THE DIFFERENTIAL DIAGNOSTIC VALUE OF CEA IN BILE OF BENIGN AND MALIGNANT BILIARY DISEASES

测定４６例胆系病人的血清及胆汁癌胚抗原（ＣＥＡ），发现胆石症与胆囊良性息肉胆汁及血清ＣＥＡ水平均在１５μｇ／Ｌ以下，统计学处理无意义。胆囊癌及胆管癌胆汁ＣＥＡ水平均在２０μｇ／Ｌ以上，明显高于血清ＣＥＡ，且与胆石症及胆囊良性从胆汁ＣＥＡ也存在非常显著差异，作者胆汁ＣＥＡ测定可为临床鉴别胆奶恶性病变癌胚怕提供一个较好的辅助诊断指标。

Levels of carcinoembryonic antigen (CEA) in bile and serum were determined in 46 patients with biliary diseases. Benign biliary diseases including cholelithiasis and gallbladder polyp showed CEA values in bile and serum less than 15μg/L, wheras malignant biliary diseases including bile duct cancer and gallbladder cancer. CEA values in bile more than 20μg/L, higher than CEA valuer in serum (P<0.01), and higher than that of benign diseases(P<0.01). We think assessment of CEA level in bile would be a good indicator for differentiating benign and malignant biliary diseases.