多指标综合评分法优选烧伤灵涂膜醇提取工艺

Optimization of Extraction Technology for Shaoshangling Film with Multiple Guidelines Grading Method

目的:优选烧伤灵涂膜的最佳醇提取工艺。方法:以浸膏得率和大黄素、盐酸小檗碱提取率为评价指标,用多指标综合评分法进行数据处理,采用正交试验考察乙醇体积分数、乙醇用量、回流时间、回流次数对提取效果的影响。结果:烧伤灵涂膜最佳醇提取工艺为:加6倍量的95%乙醇,加热回流3次,每次2 h。结论:该提取工艺设计合理,结果可靠,提取效果较好。

Objective：To optimize the preparation process for Shaoshangling Film by alcohol.Method：The contents of emodin and berberine hydrochloride and the yield of extract were used as index of appraisal.Data processing was carried out with the multiple guidelines grading method for optimizing the extraction condition.The orthogonal experimental design was introduced to optimize the conditions of the alcohol extraction technology.The experiment were involved four factors,concentration of alcohol,amount of alcohol,refluxing time,times of refluxing.Result：The best extraction technology was that refluxing 3 times,refluxing 2 hours each time and in 6 times amount of 95% alcohol.Conclusion：The process is simple,reasonable and relialbe.