羚角降压方、天麻钩藤方与高血压肝阳上亢证的方证相应性研究

Correspondence between Syndrome of Hyperactivity of Liver-yang and Prescriptions of Lingjiao Jiangya Prescription,Tianma Gouteng Prescription

目的:探索羚角降压方、天麻钩藤方与高血压肝阳上亢证证候的相应性。方法:采用附子汤+麻黄碱+盐水三因素制备大鼠高血压肝阳上亢证模型。SD大鼠50只,随机分为正常对照组、模型对照组、羚角降压方组、天麻钩藤方组、金匮肾气方组,共5组,每组10只,连续给药28 d。给药后每隔6d测定大鼠面温、抓力、收缩压、舒张压和平均动脉压,每隔14 d观察大鼠性情及毛色变化。结果:给药14 d后羚角降压方、天麻钩藤方可降低肝阳上亢模型大鼠面部温度和血压;21 d后羚角降压方、天麻钩藤方、金匮肾气方可增大大鼠抓力;28 d后3个复方均可改善毛色,其中羚角降压方、天麻钩藤方可改善躁狂症状。结论:天麻钩藤方、羚角降压方具有平肝潜阳之功效,能平抑阳亢、滋补阴虚,改善高血压肝阳上亢证之"面部烘热"、"腰膝酸软"、"狂躁易怒",降低收缩压,具有一定的方-证相应性。

Objective：To understand the correspondence between syndrome of hyperactivity of liver-yang and the prescriptions of Lingjiao Jiangya Prescription（LJP） and Tianma Gouteng Prescription（TMGTP）.Method：Aconium carmichaeli Debx.,ephedrine and salty water were used to establish the rat model of hypertension with syn-drome of hyperactivity of liver-yang.Fifty SD rats were divided into five groups,including normal control,model,LJP,TMGTP and Jinkuishenqi Prescription（JKSQP）.The medicines were given for 28 days,facial temperature,grip strength,systolic pressure,diastolic pressure and mean arterial pressure were determined per 7 days,and rat temper and coat color were observed per 14 days.Result：On day14,LJP and TMGTP could decrease the facial temperature and the blood pressure.On day21,all three prescriptions could strengthen rat grip strength.On day28,the prescriptions could ameliorate rat coat color,and LJP and TMGTP could keep rats calm.Conclusion：LJP and TMGTP could restrain hyperactivity of liver-yang,ameliorate yin-deficiency,relieve hypertension,and decrease the systolic pressure.So the correspondence between the prescriptions of LJP and TMGTP and hypertension with syn-drome of hyperactivity of liver-yang has been confirmed.