压敏胶贴剂舒筋贴活血、抗炎作用的研究

Experimental Study on Activating Blood Circulation and Anti-inflammatory Effects of Pressure-Sensitive Adhesives Shujin Paste

目的:观察压敏胶贴剂舒筋贴的活血化瘀、抗炎作用。方法:观察舒筋贴对大鼠急性血瘀模型全血黏度、血浆黏度的影响;采用大鼠肉芽肿试验、蛋清致大鼠足肿胀试验、二甲苯致小鼠耳肿胀试验,考察受试药物的抗炎作用。结果:舒筋贴可显著降低大鼠急性血瘀模型全血黏度和血浆黏度;能明显抑制大鼠肉芽肿的增生;可降低蛋清致大鼠足跖肿胀度;抑制二甲苯引起的小鼠耳廓炎性肿胀。结论:舒筋贴具较强的活血化瘀及抗炎作用。

Objective：To observe the effects of Pressure-sensitive Adhesives Shujin Paste（SJP） on activa-ting blood circulation and anti-inflammation.Method：The effects of SJP on blood viscosity and platelet aggregation of rats were observed.anti-inflammatory action was investigated through experimental granuloma in rats,the animal model was induced by injection of fresh egg white to the rats,model of ear swelling of mice was also used.Result：The SJP could reduce obviously the blood viscosity of the rabbit,could inhibit the weight gaining of granuloma in rats,and paw swelling induced by fresh egg white in rats,ear inflammation induced by xylene in mice.Conclu-sions：The SJP could promote blood circulation to remove blood stasis and anti-inflammation.