摘要
目的:探讨松针石油醚提取物抗肿瘤作用机制。方法:建立荷S 180实体瘤小鼠模型,考察松针石油醚提取物体内抗肿瘤作用。应用免疫组化法检测肿瘤组织中凋亡相关蛋白Bax,Bcl-2的表达。结果:松针石油醚提取物0.5,1.0,2.0 g.(kg.d)-1 3个剂量组对S 180实体瘤的抑瘤率分别为31.16%,41.71%,42.16%。各用药组肿瘤组织Bax表达显著增强,Bcl-2表达显著降低。结论:松针石油醚提取物具有一定的抗肿瘤活性,诱导凋亡是其机制之一。
Objective：To study the antitumor mechanism of petroleum ether extract of pine needles.Meth-od：Antitumor activity of the petroleum ether extract was determined by means of transplantable tumor（S 180） in mice.Immunohistochemical methods were employed for detection of Bax,Bcl-2 in tumor tissues.Result：The inhi-bition rate of peftroleum ether extract2.0 g.（kg.d）-1 on S 180-bearing mice was 42.16%.As for 1.0 g.（kg.d）-1 and 0.5 g.（kg.d）-1 groups,the inhibition rates were 41.71% and 31.16%.Expression of Bax in tumors was obviously increased and Bcl-2 was obviously decreased in all the therapy groups compared with the tumor control group（P 0.01）.Conclusion：Petroleum ether extract from pinee needles possesses definite antitumor effect.Ap-optosis is one of its antitumor mechanisms.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第11期177-179,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
松针
抗肿瘤
作用机制
凋亡
pine needles
antitumor
mechanism
apoptosis
