积雪草总苷抗乙酸致大鼠胃溃疡的研究

Experimental Study on Therapeutic Effect of Centella Total Glucosides on Acetic Acid-induced Gastric Ulcer in Rats

目的:研究积雪草总苷抗试验性胃溃疡的作用。方法:将大鼠随机分为空白对照组、模型组、猴头菌组、雷贝拉唑钠组、积雪草总苷高、中、低剂量组(1.62,0.81,0.405 g·kg-1),每组10只。采用乙酸法致大鼠慢性胃溃疡模型,观察积雪草总苷抗胃溃疡的作用。结果:积雪草总苷高剂量组与中剂量组大鼠乙酸致慢性胃溃疡溃疡指数显著低于模型组(P<0.05),与西药雷贝拉唑钠组无显著性差异。积雪草总苷还可显著增加IL-2(P<0.01)及免疫球蛋白Ig A(P<0.01),IgG(P<0.05),IgM(P<0.05)含量,不同程度提高细胞免疫和体液免疫水平。结论:积雪草总苷具有一定的预防和治疗胃溃疡作用,且成一定的量效关系。

Objective： To explore the therapeutic effect of Centella total glucosides on acetic acid-induced gastric ulcer in rats.Method： Rats were divided into control group,ulcer control group,Hedgehog Fungus extract group,Rabeprazole Sodium,and Centella total glucosides（1.62,0.81,0.405 g·kg-1） groups at random,10 rats in each group.After administered for 2 weeks consecutively,all the rats were sacrificed.The area of ulcer and pathological section in gastric mucosa were measured and observed.Result： Compared with ulcer control group and Hedgehog Fungus extract group,in Centella total glucosides（1.62,0.81 g.kg-1） groups,the area of ulcer was decreased significantly（P 0.05）.But compared with Rabeprazole Sodium groups,there was no significance.The level of IgM（P 0.05）,IgG（P 0.05）,IgA（P 0.01） and IL-2（P 0.01） were also significantly promoted in Centella total glucosides（1.62 g.kg-1） groups.Conclusion： Centella total glucosides（1.62,0.81 g·kg-1） has good therapeutic effect on acetic acid-induced gastric ulcer in rats,and it presents certain dose-effect relationship.