ICOS基因多态性与中国南方汉族人群多发性硬化的相关性

Study on the association between inducible costimulate gene polymorphisms and multiple sclerosis

目的探讨可诱导协同刺激分子(inducible costimulate,ICOS)基因多态性与多发性硬化(Multiple sclerosis,MS)遗传易感性。方法以来自中国南方汉族人群的83名确诊MS患者和110名非自身免疫性疾病的患者及健康志愿者为研究对象,利用PCR-RFLP技术监测ICOS基因-2394/2119位点酶切多态性。结果 ICOS-2394位点TT基因型频率MS组明显高于对照组(MS33.7%VS对照组10.9%,P<0.001),携带T等位基因可增加MS患病危险(OR=3.482,P<0.001),ICOS-2119位点TT基因型MS组明显低于对照组(MS4.8%vs对照组15.5%,P<0.05)。结论中国南方汉族人群ICOS基因多态性与MS发病相关,该基因可能是MS的易感基因。

Objective To investigate inducible costimulate （ICOS） gene polymorphisms and susceptibility to multiple sclerosis （MS）. Methods Eighty three patients with MS and one hundred and ten controls selected from healthy individuals and hospital staff in Han population of South China of non-autoimmune diseases were studied by genotype of the three gene using PCR-RFLP. Results The frequency of ICOS-2394 TT genotype was significantly higher in MS patients than in controls （MS 33.7% VS controls 10.9%,P〈0.001）,and MS patients had an increase in the carrier frequency of the T allele （OR=3.482,P〈0.001）,while ICOS-2119 TT genotype was significantly lower in MS patients than in controls （MS 4.8% vs controls 15.5%,P〈0.05）. Conclusion ICOS-2394C/T,-2119T/C polymorphisms might be related with MS in Han population of South China,which suggests ICOS might be one of genes susceptibility to MS or be linked with susceptibility genes.