1Seshadri S,Beiser A,Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer' s disease [ J ]. N Engl J Med, 2002,346:476-483.
2Sacco RL, Roberts JK, Jacobs BS. Homocysteine as a risk factor for ischemic stroke: an epidemiological story in evolution [ J]. Neuroepidemiology, 1998,17 (4) : 167-173.
1McQuillan BM, Beilby JP, Nidorf M, et al. Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS).
2Vermeulen EG, Rauwerda JA, van den Berg M, et al. Homocysteinelowering treatment with folic acid plus vitamin B6 lowers urinary albumin excretion but not plasma markers of endothelial function or C-reactive protein: further analysis of secondary end-point
3van Dijk RA, Rauwerda JA, Steyn M, et al. Long-term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stif
4Vermeulen EG, Niessen HW, Bogels M, et al. Decreased smooth muscle cell/extracellular matrix ratio of media of femoral artery in patients with atherosclerosis and hyperhomocysteinemia. Arterioscler Thromb Vasc Biol, 2001, 21:573 -577.
5Kristensen B, Malm J, Nilsson TK, et al. Hyperhomocysteinemia and hypofibrinolysis in young adults with ischemic stroke. Stroke, 1999,30:974 - 980.
6Selhub J. Homocysteine metabolism. Annu Rev Nutr, 1999, 19:217 -246.
7Yoo JH, Chung CS, Kang SS. Relation of plasma homocyst(e)ine to cerebral infarction and cerebral atherosclerosis. Stroke, 1998, 29:2478 - 2483.
8Ray JG, Harvey DT. Hyperhomocysteinemia as a cause of premature stroke in a young patient. Arch Phys Med Rehabil, 1998, 79:343 - 345.
9Tan NC, Venketasubramanian N, Saw SM, et al. Hyperhomocyst(e)inemia and risk of ischemic stroke among young Asian adults.Stroke, 2002, 33:1956 - 1962.
10Torbus-Lisiecka B, Bukowska H, Jastrzebska M, et al. Lp(a), homocysteine and a family history of early ischemic cerebral stroke. Nutr Metab Cardiovasc Dis, 2001, 11 (Suppl 5): 52 - 59.
7Biselli P M, Guerzoni A R, de Godoy M F, et al. Genetic polymor- phisms involved in folate metabolism and concentrations of methyl- malonic acid and folate on plasma homocysteine and risk of coro- nary artery disease[J]. J Thromb Thrombolysis, 2010, 29( 1 ) :32.
8Roubin G S, Yada J S, Lyer S S, et al. Carotid stentsuppoted ansin- plasty: aaneurqvasculaar intenentirn to prqvent stoke[J]. Am J Crdi- ol, 1996, 78(3A):8.
9Jin L, Caldwell R B, H-Masters T, et al. Homocysteine induces en- dothelial dysfunction via inhibition of arginine transport[J].J Physiol Pharmacol, 2007, 58 ( 2 ): 191.
10Wang G, Dai J, Mao J. Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia[J]. Atherosclerosis, 2005, 179(2 ):395.
