维生素E对胸腺T细胞CD抗原分化及其作用机理的研究

Effects and Mechanism of Vitamin E on T Lymphocyte Differentiation in the Mice Thymus

含ＶＥ０、５０、１５０、１０００ｍｇ／ｋｇ饲料喂饲４组初断奶小鼠８周后，观察ＶＥ诱导胸腺Ｔ淋巴细胞ＣＤ抗原分化的作用，以及对腹腔ＭΦ诱生ＩＬ－１作用的影响。结果表明：补充ＶＥ提高胸腺ＣＤ５表面抗原阳性Ｔ细胞总数、ＣＤ４表面抗原阳性细胞数（Ｔｈ亚群）、降低ＣＤ８表面抗原阳性细胞（Ｔｓ亚群）百分率；补充ＶＥ提高腹腔ＭΦ诱导ＩＬ－１的生成水平；大剂量补充ＶＥ（２０倍需要量）时，提高免疫反应的作用低于３倍需要量组，但未出现低于需要量组的反应。结果提示：ＶＥ促进Ｔ细胞的成熟、分化，并可能是通过提高Ｔｈ／Ｔｓ比值及诱发ＭΦ产生ＩＬ－１进行Ｔ细胞免疫反应的调节。

ice were divided into four groups,including0,50,1000mg VE per kg diet groups,and fed for 8 weeks to evaluate the effects of vitamin E on differentiation of T lymphocyte specific subgroups in thymus and IL 1 production by celiac macrophage.The results showed that there were significant increase in the percentage of T cell,Th subgroup,Th/Ts ratio and decrease in Ts subgroup in vitamin E supplemental groups.IL 1 Production by celiac macrophage was enhanced following vitamin E supplement.In above tests, it had the stronger reaction in three times requirement group than in twenty times requirement group,and had a trend to decline following high dose vitamin E supplement,but no impair reaction was founded.