BSO和NAC对镉急性毒性影响的实验研究

Experimental Study on the Effects of BSO and NAC on Cadmium Toxicity in Syrian Hamsters

给仓鼠皮下注射不同剂量氯化镉后２４小时，测定血清ＬＤＨ、ＧＰＴ，尿ＬＤＨ和蛋白质，肝脏和肾皮质镉和ＧＳＨ含量。结果发现高剂量染镉后血清ＬＤＨ和ＧＰＴ活性，肝肾镉含量和肾皮质ＧＳＨ含量增高。表明急性染镉可引起仓鼠肝脏损害。给仓鼠ＢＳＯ或ＮＡＣ预处理后再投与镉，发现ＢＳＯ可增加镉的肝肾毒性，而ＮＡＣ能拮抗镉的肝毒性，增加镉的肾毒性。推测其机理与ＢＳＯ或ＮＡＣ预处理后使机体细胞内ＧＳＨ含量改变有关。

Syrian hamsters were given subcutaneous injections of cadmium chloride in different dose and 24 hours later serum LDH and GPT,urinary LDH activities and protein contents,Cd and GSH concentrations in the liver and renal cortex were determined.The results showed that serum LDH adn GPT activities,Cd concentations in the liver and renal cortex and GSH concentraion in the renal cortex in the higher dose Cd treated group were increased significantly.It was indicated that acute Cd administration induced liver damage in hamsters.Animals were also pretreated with BSO or NAC before Cd administration.It was found that BSO enhanced Cd induced hepatic and renal toxicity and NAC offset Cd induced hepatic toxicity,enhanced Cd induced renal toxicity.The mechanism may be BSO or NAC pretreatment causing the changes of intracellular GSH level.