阻断妊娠梅毒母婴传播综合干预疗效分析

Blocking Pregnancy Syphilis Mother-to-Child Transmission Comprehensive Interference Effect Analysis

目的：探讨综合干预阻断妊娠梅毒母婴传播的效果,以降低围产儿的死亡率。方法：综合干预治疗;注射苄星青霉素G 240万单位,肌肉注射,每周1次,共4次;青霉素G静滴,从最小量320万单位到最大量1 200万单位逐渐增大剂量;定期复查快速血浆反应素试验、梅毒螺旋体明胶颗粒凝集试验。结果：早期诊断、足量正规治疗,胎传梅毒发生率两组对比,未治疗组明显高于治疗组,经治疗观察,在孕34周以后接受治疗者,胎儿将有50%~70%的机会感染梅毒,未经治疗孕妇几乎100%通过胎盘将病原体垂直传给胎儿。结论：早期诊断妊娠梅毒是阻断、改善妊娠梅毒结局和降低胎传梅毒患儿发生率的关键;通过综合干预治疗、阻断母婴传播,降低围产儿的死亡率效果显著。

Objective：Integrated intervention blocking effects of pregnancy syphilis mother-to-child transmission,in order to reduce the perinatal mortality.Methods：Comprehensive interventions,Injection of benzyl star penicillin G 2.4 million units,muscular,weekly 1,4 times,Penicillin G,from the static drops to the small 3.2 million units of 12 million units increased doses,Periodically review RPR、TPPA.Results：Early diagnosis and treatment,tire sufficient normal incidence of two groups of syphilis preached,untreated group in treatment group was obviously higher than that in the treatment of observation,after receiving treatment at 34 weeks and fetal there will be 50%～70% chance of syphilis infection,untreated pregnant almost 100%through the placenta pathogen will pass fetal vertical.Conclusion：Early diagnosis is blocking,improve pregnancy syphilis pregnancy outcome and reducing tire syphilis preached the key;the incidence of syphilis children through the comprehensive interventions,blocking mother-to-child transmission,reduce the perinatal mortality effect is remarkable.