Morisky服药依从性量表在肺结核患者中的应用

Application of the morisky medication adherence scale on pulmonary tuberculosis patients

目的通过测量和比较肺结核患者对FDC和板式组合药的服药依从性,探讨Morisky服药依从性量表用于肺结核患者服药依从性测量的可行性。方法在临床随机对照试验中,研究组使用FDC,对照组使用板式组合药,用Morisky服药依从性量表对2组患者进行问卷调查。结果将Morisky服药依从性量表用于肺结核患者时,量表的克朗巴哈α系数为0.64。共有463例肺结核患者被纳入研究,其中研究组230例,对照组233例,研究组服药依从性高于对照组,差异有统计学意义(Z=-6.001,P=0.000)。结论 FDC患者服药依从性高于板式组合药;Morisky服药依从性量表用于肺结核患者服药依从性的测量时具有较好的内在信度和敏感性。

Objective To explore the feasibility of the Morisky Medication Adherence Scale 8-item version（MMAS 8-item version） being applied on pulmonary tuberculosis（PTB） patients,and to measure and compare the adherence of PTB patients treated with fixed-does combination（FDC） and blister pack drugs. Methods In a randomized controlled clinical trial,the experimental group（EG） treated with FDC and the control group（CG） treated with blister pack drugs.MMAS 8-item version was applied to patients in both groups by questionnaire survey. Results Cronbach＇s coefficient was 0.64 in this study.There were 230 patients in EG,and 233 in CG..The adherence in EG was significantly higher than CG（Z=-6.001,P=0.000）. Conclusion The adherence of PTB patients treated with FDC was better than those paitents treated with blister pack drugs.The MMAS 8-item version has a good reliability and sensitivity,could be applied on the PTB patients.