欣母沛在剖宫产术中行子宫肌瘤剔除中应用临床分析

Clinical study of efficacy and safety of hemabate in uterine myomectomy and cesarean section

目的探讨欣母沛在剖宫产同时行子宫肌瘤剔除术中的疗效及安全性。方法前瞻性分析我院73例剖宫产同时行子宫肌瘤剔除术的患者,将其随机分为实验组(欣母沛组37例)及对照组(缩宫素组36例),比较两组在术中出血、住院天数、子宫下降高度、血红蛋白(Hb)下降,恶露持续时间方面的差异。结果欣母沛组的术中出血、血红蛋白(Hb)下降和恶露持续时间明显低于缩宫素组(均为P<0.05),术后子宫下降高度则明显高于缩宫素组(P<0.05)。欣母沛组的不良反应高于缩宫素组(P<0.05),但一般较轻,不需特殊处理。结论欣母沛应用于剖宫产术中行肌瘤剔除术在止血方面明显优于缩宫素,术后观察子宫收缩明显优于缩宫素组,有一定的应用前景。

Objective To prospectively study the efficacy and safety of hemabate on prevention of hemorrhage in uterine myomectomy and cesarean section.Methods A total of 73 pregnant women were randomly divided into group hemabate（37 women） and group oxytocin（37 women）.Some data were collected such as the amount of bleeding during the operation,the change of Hb,the height of uterus desending and the duration of lochia.The side effects of each group were observed.Results The amount of bleeding during the operation,the descending of Hb and the duration of lochia in group hemabate were significantly lower than those in group oxytocin（P0.05）.The height of uterus desending in group hemabate were much higher than those in group oxytocin（P0.05）.Adverse events were recorded more often in the group hemabate but the major of them was benign and extra treatment was not needed.Conclusion Hemabate is effective and safe on prevention of hemorrhage in uterine myomectomy and cesarean section.