C反应蛋白在儿童溃疡性结肠炎患者临床疗效和预后评估中的作用

Evaluation of the efficacy and prognosis of C-reactive protein in children with ulcerative colitis

目的对儿童溃疡性结肠炎(UC)患者进行检测血清中C反应蛋白(CRP)水平,并分析CRP与UC患儿的临床疗效和预后之间的关系。方法收集25例活动期UC患儿、14例缓解期UC患儿及32例健康儿童血清标本,检测CRP水平,研究CRP与UC疾病活动程度的关系。对UC患儿进行有效治疗,进一步观察CRP与临床治疗效果和预后的相关性。结果活动期UC患儿血清CRP水平比缓解期患儿及正常儿童明显升高,差异有统计学意义(P<0.001)。活动性UC患儿经有效治疗后,病情缓解,血清中CRP水平显著下降(P<0.001),接近缓解期UC患儿和健康者。结论 CRP在活动性UC患儿血清中显著升高,并能判断疾病的预后转归。

Objective To determine the level of serum C-reactive protein（CRP） in children with ulcerative colitis（UC） and study the relationship among CRP,clinical efficacy and prognosis.Methods CRP in serum was detected in 25 children with active UC,14 children with UC in remission,and 32 healthy control children.Relationship between CRP and disease activities was evaluated subsequently.Active UC patients were treated and serum CRP was also examined to investigate the association with clinical efficacy and prognosis.Results The level of CRP was observed to be significantly higher in serum of children with active UC than those in children in remission and in healthy controls（P 0.001）.Moreover,CRP was found to be significantly decreased in active UC children after effective treatment（P 0.001）. Conclusion CRP is markedly increased in serum of children with active UC and can predict the prognosis of disease.