不同剂量辛伐他汀在急性冠脉综合征患者中的早期应用

Effects of different doses of simvastatin on acute coronary syndrome

目的观察急性冠脉综合征(ACS)发生后24 h内应用不同剂量辛伐他汀的疗效与安全性。方法将117例ACS患者随机分为两组,分别给予辛伐他汀20 mg/d与40 mg/d,每晚1次,用药3个月后观察两组患者血脂达标情况和高敏C-反应蛋白(hs-CRP)及心血管事件的发生率及药物不良反应。结果①两组治疗1、3个月后的总胆固醇、低密度脂蛋白胆固醇、hs-CRP水平均明显降低,且40 mg/d组在各时间段血脂达标情况优于20 mg/d组,住院及随访期间心脏事件发生率也明显减少。②两组均未见不良反应。结论 ACS患者应用20 mg/d及40 mg/d的辛伐他汀均能有效降脂,40 mg/d辛伐他汀调脂及减少心血管事件更佳,且治疗过程中无严重不良反应。

Objective To observe the acute coronary syndrome（ACS） occurred within 24 hours after application of different doses of simvastatin efficacy and safety.Methods One hundred and seventeen patients with ACS were randomly divided into 2 groups were given within 24 hours of simvastatin 20 mg and 40 mg once every night,medication 3 months observation of two patients lipid compliance and high-sensitivity C-reactive protein（hs-CRP） and cardiovascular events in the incidence and adverse drug reactions.Results ①Two group therapy 1 month,3 months of total cholesterol（TC）,low density lipoprotein（LDL-C）,hs-CRP were significantly reduced,and the 40 mg group than in 20 mg group in each time period was better than 20 mg of lipid compliance group,hospitalization and incidence of cardiac events during follow-up is also significantly reduced.②Two groups were no adverse reactions.Conclusion ACS patients with 20 mg/d and 40 mg/d of simvastatin can be effective lipid-lowering,40 mg/d of simvastatin on lipid and to reduce cardiovascular events better,and the course of treatment without serious adverse reactions.