蒌叶茎中生物碱和木脂素类化学成分研究

Alkaloids and lignans from stems of Piper betle

目的:对蒌叶茎中生物碱和木脂素类化学成分进行研究。方法与结果:采用常压硅胶柱色谱、反相色谱、薄层色谱及Sephadex LH-20柱色谱法等分离手段,从蒌叶茎70%丙酮提取物的乙酸乙酯部分中分离得到10个化合物,通过理化性质和波谱数据,分别鉴定为胡椒碱(1),墙草碱(2),N-isobutyl-2E,4E-dodecadienamide(3),dehydropipernonaline(4),piperdar-dine(5),piperolein-B(6),guineensine(7),(2E,4E)-N-isobutyl-7-(3′,4′-methyl-enedioxyphenyl)-2,4-heptadienamide(8),丁香脂素-O-β-D-葡萄糖苷(9),松脂素(10)。结论:所有化合物均为首次从该植物中分离得到,其中化合物9,10是首次从该属植物中得到。

Alkaloids and lignans from the stems of Piper betle were studied.Compounds were isolated and purified by repeated silica gel,reverse phase silica gel,Sephadex LH-20 column chromatography and preparative thin layer chromatography.The structures were elucidated on the basis of spectral analysis.From the ethyl acetate soluble fractions of the 70% acetone extract,ten compounds were isolated and identified as piperine（1）,pellitorine（2）,N-isobutyl-2E,4E-dodecadienamide（3）,dehydropipernonaline（4）,piperdardine（5）,piperolein-B（6）,guineensine（7）,（2E,4E）-N-isobutyl-7-（3′,4′-methylenedioxyphenyl）-2,4-heptadienamide（8）,syringaresinol-O-β-D-glucopyranoside（9）,pinoresinol（10）.All Compounds were isolated from the plant for the first time,and compounds 9 and 10 were isolated firstly from the genus.