大鼠多巴胺D_1受体介导二氢埃托啡位置偏爱效应(英文)

Dihydroetorphine-induced place preference was mediated by dopamine D_1 receptors in rats

目的:研究不同的多巴胺(DA)受体拮抗剂对二氢埃托啡(DHE)奖赏效应的影响,方法:采用条件性位置偏爱模型评价DHE的奖赏效应,DA受体拮抗剂采取外周给药或直接到伏隔核内,结果:DHE(0.05、0.5和5.0μg·kg^(-1),sc)产生位置偏爱效应,氟哌啶醇、Sch-23390 sc或直接注射到伏隔核都能抑制DHE(0.5μg·kg^(-1),sc)的偏爱效应;而l-舒必利和螺哌隆在这两种给药途径下都不影响DHE的偏爱效应,结论:伏隔核中D_1受体(而不是D_2受体)在DHE偏爱效应中起关键作用。

AIM: To study the influence of dopamine (DA) receptor antagonists upon the rewarding property of dihydroetorphine (DHE). METHODS: Conditioned place preference ( CPP ) paradigm was used to characterize the rewarding effect of DHE. DA receptor antagonists were injeted administered subcutaneously or peritoneally and microinjected into nucleus accumbens (NAcc). RESULTS: DHE (0.05, 0.5, and 5.0 μg·kg-1, sc) produced place preference (P <0.01). Both the DA receptor antagonist haloperidol and the selective D1 receptor antagonist Sch-23390 attenuated the place preference produced by DHE (0.5 μg·kg-1, sc).l-Sulphide and spiperone, selective D2 receptor antagonists, had no such effects. CONCLUSION: The D1(but not D2) receptors in NAcc are crucial in the mediation of the rewarding effect of DHE.