肾移植后糖尿病(附13例报告)

Diabetes mellitus following renal transplantation-A report of 13 cases

目的探讨肾移植与糖尿病发病的关系。方法对７６例肾移植患者的糖尿病（ＰＴＤＭ）发病情况进行了观察。结果共确诊ＰＴＤＭ１３例，发病率１７．１％，发病以高龄、高体重及产生向心性肥胖者多见，与阳性糖尿病家族史及不良肝肾功能有关，但与抗排斥药物剂量无明显关系。ＰＴＤＭ组并发高渗性非酮性昏迷２例（１５．４％），各种感染９例（６９．２％），死亡３例（２３．１％）。结论肾移植后糖代谢紊乱是一普遍现象，ＰＴＤＭ有相当的危害性。

objective To explore the relationship between renal transplantation and the pathogenesis of diabetes mellitus. Methods The incidence of postrenal diabetes mellitus (PTDM) in 76 patients was observed. Results The total morbidity of PTDM was 17.1% (13/76) with a higher incidence in old patients, heavy weight and central obesity. The incidence of PTDM was correlated with the positive history of family diabetes and unstable liver or renal function, but had no relationship with dosage of immunosuppressants. In this group, nonketotic hyperrosmotic coma was complicated by 2 PTDM patients (15.4%), varieties of infection by 9 patients (69.2%). The mortality was 23.1%. Conclusion Glucose metabolic disorder after renal transplantation was a common phenomenon. PTDM may bring grievous perniciousness and must take it seriously.