幽门螺杆菌的耐药性及根除治疗对策

The resistance of helicobacter pylori to antibiotics and the treatment strategies

根除幽门螺杆菌是预防和治疗幽门螺杆菌相关疾病的重要手段,然而随着抗生素耐药的逐年增加,质子泵抑制剂+阿莫西林+甲硝唑或克拉霉素的标准治疗方案根除率逐年下降。本文介绍了当前幽门螺杆菌对抗生素的耐药特点、影响耐药产生的相关因素、避免抗生素耐药产生的治疗对策,以及根除治疗后细菌的再感染和复发问题。

Sununary：Eradication of Helicobacter pylori takes an important role in the prevention and treatment of the associated diseases. Accompanied with the increasing resistance of H. pylori to antibiotics, the eradication rate of the combination of a proton pump inhibitor with two antibiotics has fallen. Growing resistance often parallels antibi- otic consumption and may vary within patient groups. Treatment strategies under this situation are suggested, and the recurrence of H. pylori infection after eradication is also considered in this paper.