胆囊癌52例预后的多因素分析

MULTIVARIATE ANALYSIS OF PROGNOSTIC FACTORS FOR 52 CASES OF GALLBLADDER CARCINOMAS

目的回顾性分析胆囊癌患者的临床资料并进行随访,探讨影响胆囊癌患者预后的独立因素。方法回顾性总结福建医科大学附属协和医院1999年1月-2009年6月间经手术切除并具有完整资料的原发性胆囊癌52例,进行单因素及多因素预后分析。结果 52例均获随访,单因素分析显示患者肿瘤大小、Nevin分期、肿瘤分化程度、血管侵犯、淋巴管浸润及手术方式均为影响预后的因素。Cox多因素分析表明肿瘤的Nevin分期、淋巴管浸润及手术方式是影响患者术后生存时间的独立因素。结论 Nevin分期、淋巴管浸润及手术方式为影响胆囊癌患者术后生存的独立因素。

Objective To evaluate the independent prognostic factors influencing gallbladder carcinoma through the retrospective analysis of the clinical data of 52 cases of gallbladder carcinoma. Methods Fifty -two patients with gallbladder carcinoma surgically treated from 1999 to 2009 in the Affiliated Union Hospital of Fujian Medical University were followed up and studied by univariate and multivariate analysis. Results Fifty- two cases were followed up. Using univariate analysis, the tumor size, Nevin stage, tumor differentiation, vascular invasion , lymphovascular invasion, and surgical ＂manage all showed significant correlation to the prognosis. In Cox multivariant survival analysis, the Nevin stage, lymphovascular invasion, and surgical treatment were independent prognostic indicators. Conclusion The Iindependent prognostic factors of survival after the gallbladder carcinoma operation might be the Nevin stage, lymphovascular invasion, and surgical methods.