摘要
Objective: To assess the therapeutic effect and adverse reaction of Qufeng Zhidong Recipe (a recipe for dispelling wind to stop abnormal movement) used to treat children with tic disorder (TD). Methods: The enrolled patients were randomized into a TCM group (31 cases) treated with Qufeng Zhidong Recipe and a Western medicine group (30 cases) treated with haloperidol and trihexyphenidyl. Two courses of treatment were observed with 12 weeks as one course. The therapeutic effect and adverse reaction were assessed with Yale Global Tic Severity Scale (YGTSS), Tic Symptom Score Scale (TSSS), TCM Syndrome Score Scale (TCMSSS), Treatment Emergent Symptom Scale (TESS) and laboratory examinations. Results: The total effective rate was 100% in the TCM group and 60% in the Western medicine group with statistical significance in difference (P<0.05). All the scores in the TCM group were better than those in the Western medicine group (P<0.05). Conclusion: Qufeng Zhidong Recipe can obviously relieve the symptoms and signs of TD children without toxic side-effects.
Objective： To assess the therapeutic effect and adverse reaction of Qufeng Zhidong Recipe （a recipe for dispelling wind to stop abnormal movement） used to treat children with tic disorder （TD）. Methods： The enrolled patients were randomized into a TCM group （31 cases） treated with Qufeng Zhidong Recipe and a Western medicine group （30 cases） treated with haloperidol and trihexyphenidyl. Two courses of treatment were observed with 12 weeks as one course. The therapeutic effect and adverse reaction were assessed with Yale Global Tic Severity Scale （YGTSS）, Tic Symptom Score Scale （TSSS）, TCM Syndrome Score Scale （TCMSSS）, Treatment Emergent Symptom Scale （TESS） and laboratory examinations. Results： The total effective rate was 100% in the TCM group and 60% in the Western medicine group with statistical significance in difference （P〈0.05）. All the scores in the TCM group were better than those in the Western medicine group （P〈0.05）. Conclusion： Qufeng Zhidong Recipe can obviously relieve the symptoms and signs of TD children without toxic side-effects.
基金
supported by the Shanghai Construction of the clinical advantages of Traditional Chinese Medicine on Encephalopathy, China (No.2008YSZK004)
Modernization of Chinese Medicine of Shanghai Science and Technology Commission, China (No.09Dz19753000)
the Shanghai Scientific Research Foundation for Young Scientists, China (No.2008QN052)
the Special Foundation of Shanghai Science and Technology Commission, China (No.0852nm05500)
关键词
治疗效果
抽动
儿童
止动
临床
不良反应
中医证候
实验室检查
tic disorder （TD）
Qufeng Zhidong Recipe
Yale Global Tic Severity Scale （YGTSS）
Tic Symptom Score Scale （TSSS）
TCM Syndrome Score Scale （TCMSSS）
Clinical observation
