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Dickkopf-1与肿瘤 被引量：3

Dickkopf-1 and tumor
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摘要 Dickkopf-1（DKK-1）通过Wnt/β-连环蛋白（β-catenin）经典信号传导途径以及Wnt非经典信号传导途径在体内诱导多种肿瘤细胞凋亡,调控多种肿瘤细胞的骨转移以及促进某些肿瘤细胞的浸润和侵袭,从而在肿瘤的发生和发展方面发挥重要作用. Dickkopf-1 （DKK-1） plays an important role in the initiation and progression of many human cancers. It can induce apoptosis of a wide variety of tumor cells in vivo through both the canonical Wnt/β-catenin signal transduction pathway and the non-canonical Wnt signal transduction pathway. In addition, DKK-1 can modulate bone metastasis and promote the invasion and infiltration of some tumor cells.
作者 朱建坤(综述) 李道堂(审校)
机构地区 山东省肿瘤医院胸外科
出处 《国际肿瘤学杂志》 CAS 2010年第8期565-567,共3页 Journal of International Oncology
关键词 肿瘤 WNT蛋白质类 DICKKOPF-1 Neoplasms Wnt proteins Dickkopf-1
分类号 R979.1 [医药卫生—药品]
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参考文献15

  • 1González-Sancho JM,Aguilera O,García JM,et al.The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer.Oncngene,2005,24(6):1098-1103.
  • 2Chamorro MN,Schwartz DR,Vonica A,et al.FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.EMBO J,2005,24(1):73-84.
  • 3Oyama T,Yamada Y,Hata K,et al.Further upreulation of betacatenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice.Carcinogenesis,2008,29(3):666-672.
  • 4Endo Y,Beauchamp E,Woods D,et al.Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing rumor cells via a Frizzled3-and c-Jun N-terminal kinase-dependent mechanism.Mol Cell Biol,2008,28 (7):2368-2379.
  • 5Yamabuki T,Takano A,Hayama S,et al.Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas.Cancer Res,2007,67(6):2517-2525.
  • 6Sheng SL,Huang G,Yu B,et al.Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer.Clin Chem,2009,55(9):1656-1664.
  • 7Chamorro MN,Schwartz DR,Vonica A,et al.FGF-20 and DKK1 are tramscriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.EMBO,2005,24 (1):73-84.
  • 8Forget MA,Turcotte S,Beauseigle D,et al.The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types.Br J Cancer,2007,96(4):646-653.
  • 9Pukrop T,Klemm F,Hagemann T,et al.Wnt 5a signaling is critical for macrophage -induced invasion of breast cancer cell lines.Proc Natl Acad Sci USA,2006,103(14):5454-5459.
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同被引文献41

  • 1周岗,陈伟,付小兵.皮肤发育与再生修复过程中Wnt信号途径的生物学特性研究[J].中国临床康复,2004,8(29):6472-6473. 被引量：3
  • 2余艳军,万晓桢,于彬,游海燕,舒惠群,姚根富,覃文新.Dickkopf(DKK1)在肝癌组织及多种人肿瘤细胞系中的表达分析[J].肿瘤,2006,26(12):1109-1112. 被引量：16
  • 3Uren A,Fallen S,Yuan H,et al. Activation of the canonical Wntpathway during genital keratinocyte transformation ; a model forcervical cancer progression [ J ]. Cancer Res, 2005 , 65 ( 14 ):6199-6206.
  • 4Malhotra S,Kincade PW. Wnt-related molecules and signalingpathway equilibrium in hematopoiesis[ J]. Cell Stem Cell,2009,4(1):27-36.
  • 5van der Meide WF,Snellenberg S,Meijer C],et al. Promoter meth-ylation analysis of WNTjS-catenin signaling pathway regulators todetect adenocarcinoma or its precursor lesion of the cervix[ J] ? Gy-necol Oncol,2011,123(1) :116-122.
  • 6Veeck J,Dahl E. Targeting the Wnt pathway in cancer: the emer-ging role of Dickkopf-3 [ J] . Biochim Biophys Acta,2012,1825(1):18-28.
  • 7Clevers H. Wnt/beta-catenin signaling in development and disease[J]. Cell,2006,127(3) :469480.
  • 8Glinka A,Wu W,Delius H,et al. Dickkopf-1 is a member of a newfamily of secreted proteins and function in head induction[ J]. Na-ture,1998,391(6665) :357-362.
  • 9Oyama T, Yamada Y, Hata K,et al. Further upregulation of beta-catenin/Tcf transcription is involved in the development of macro-scopic tumors in the colon of ApcMin/ + mice[ J] ? Carcinogenesis,2008,29(3):666-672.
  • 10Endo Y, Beauchamp E, Woods D, et aL Wnt-3a and Dickkopf-1stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3-and c-Jun N-tenninal kinase-dependent mechanism [ J]. Mol CellBiol,2008,28(7) :2368-2379.

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国际肿瘤学杂志
2010年 第8期

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