摘要
Toll样受体（TLR）是天然免疫的主要受体,促进适应性免疫.TLR不仅表达在免疫细胞上,也表达在上皮细胞和肿瘤细胞上.与内外源性配体结合后,激活胞内信号通路,释放大量炎症因子,营造炎性微环境,导致肿瘤形成、侵袭和转移.
Toll-like receptor （TLR） plays a crucial role in innate immune response and the subsequent induction of adaptive immunity. TLR is expressed on immune cells as well as epithelial cells and tumor cells. When endogenous and exogenous ligands bind with TLR, TLR signaling pathways are activated and a large number of inflammatory cytokines are released, creating an inflammatory microenvironment and leading to tumor formation, invasion and metastasis.
出处
《国际肿瘤学杂志》
CAS
2010年第8期567-569,共3页
Journal of International Oncology
关键词
TOLL样受体
肿瘤形成过程
肿瘤侵润
肿瘤转移
Toll-like receptors
Neoplastic processes
Neoplasm invasiveness
Neoplasm metastasis
