摘要
血管生成拟态(VM)能促进肿瘤细胞的生长、侵袭和转移。VM的形成机制与上皮细胞激酶、脂酰肌醇-3激酶、缺氧诱导因子1等多种蛋白分子相关,局部微环境也是重要的调控因素。
Vasculogenic mimicry(VM) can promote tumor growth, invasion, and metastasis. The formation of VM is regulated by various proteins including epithelial cell kinase, phosphoinositide-3 kinase, and hypoxia-inducible factor 1. Local microenvironment also plays an important role in regulating VM formation.
出处
《国际肿瘤学杂志》
CAS
2010年第8期576-578,共3页
Journal of International Oncology
关键词
新生血管化
病理性
肿瘤
缺氧诱导因子1
血管生成拟态
Neovascularization, pathologic
Neoplasms
Hypoxia-inducible factor 1
Vasculogenic mimicry