血管生成拟态的形成机制及其调控因素与临床意义

Formation mechanisms, regulating factors and clinical significance of vasculogenic mimicry

血管生成拟态（VM）能促进肿瘤细胞的生长、侵袭和转移。VM的形成机制与上皮细胞激酶、脂酰肌醇-3激酶、缺氧诱导因子1等多种蛋白分子相关，局部微环境也是重要的调控因素。

Vasculogenic mimicry（VM） can promote tumor growth, invasion, and metastasis. The formation of VM is regulated by various proteins including epithelial cell kinase, phosphoinositide-3 kinase, and hypoxia-inducible factor 1. Local microenvironment also plays an important role in regulating VM formation.