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岩藻聚糖硫酸酯抗肿瘤作用机制 被引量：1

Anti-tumor mechanisms of fucoidan
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摘要 岩藻聚糖硫酸酯是一种具有多种生物活性的硫酸多糖，如抗凝血、降血脂、抗肿瘤等，抗肿瘤作用机制包括免疫调节、诱导肿瘤细胞凋亡和抑制新血管生成等。 Fucoidan is a kind of sulfated polysaccharide with a variety of biological properties including anti-coagulation, lipid lowering and anti-tumor. Its anti-tumor mechanisms include immune regulation, induction of tumor cell apoptosis and inhibition of angiogenesis and so on.
作者 毕红霞(综述)
机构地区 山东省威海市立医院药剂科
出处 《国际肿瘤学杂志》 CAS 2010年第8期582-583,共2页 Journal of International Oncology
关键词 岩藻聚糖硫酸酯 肿瘤 细胞凋亡 新生血管化 Fucoidan Neoplasms Apoptosis Neovascularization
分类号 R979.5 [医药卫生—药品]
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参考文献14

  • 1Li B,Lu F,Wei X,et al.Fucoidan:structure and bioactivity.Molecules,2008,13(8):1671-1695.
  • 2Kim KJ,Lee OH,Lee HH,et al.A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague-Dawley rats.Toxicology,2010,267 (1-3):154-158.
  • 3Maruyama H,Tamauchi H,Iizuka M,et al.The role of NK cells in antitumor activity of dietary fucoidan from Undaria pinnatifida sporophylls (Mekabu).Planta Med,2006,72 (15):1415-1417.
  • 4Aisa Y,Miyakawa Y,Nakazato T,et al.Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways.Am J Hematol,2005,78(1):7-14.
  • 5Teruya T,Konishi T,Uechi S,et al.Anti-proliferative activity of oversulfated fucoidan from commercially cultured Cladosiphon okamuranus TOKIDA in U937 cells.Int J Biol Macromol,2007,41(3):221-226.
  • 6Hyun JH,Kim SC,Kang JI,et al.Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells.Biol Pharm Bull,2009,32(10):1760-1764.
  • 7Soeda S,Kozako T,Iwata K,et al.Oversulfated fucoidan inhibits the basic fibroblast growth factor-induced tube formation by human umbilical vein endothelial cells:its possible mechanism of action.Biochim Biophys Acta,2000,1497(1):127-134.
  • 8Koyanagi S,Tanigawa N,Nakagawa H,et al.Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities.Biochem Pharmacol,2003,65(2):173-179.
  • 9Yang C,Chung D,Shin IS,et al.Effects of molecular weight and bydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida.Int J Bio Macromol,2008,43 (5):433-437.
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国际肿瘤学杂志
2010年 第8期

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