血管球瘤32例临床病理分析

Glomus tumor:a clinicopathologic analysis of 32 cases

目的探讨血管球瘤(GT)的临床及病理学特征。方法回顾性分析32例血管球瘤的临床资料、组织学形态及免疫组化染色结果。结果血管球瘤好发于甲下,疼痛明显;组织学上瘤细胞呈规则的圆形,胞质淡嗜伊红色,细胞境界清晰,核圆形、居中,瘤细胞巢间可见丰富的薄壁血管,间质含丰富的神经纤维和肥大细胞。免疫组化示vimentin、SMA和HHF-35(+),S-100和CD34(-)。结论血管球瘤多属于良性肿瘤,来源于血管球变异的平滑肌,结合其临床症状、好发部位、组织病理学特点和免疫组化标记可做出准确诊断。恶性血管球瘤要慎诊断,而疼痛可能与神经纤维、肥大细胞之间相互作用有关。

Objective To investigate the clinicopathologic features of glomus tumor （GT）. Methods The clinical and pathologic profiles of 32 cases were retrospectively analysed. Results Glomus tumors most commonly occured in the subungnal region, with severe pain to pressure and temperature hypersensitivity. The tumor consisted mainly of round to ovoid glomus cells around the thin-walled blood vessels, and stroma rich in nerve fibers and mast cells. The tumor cells expressed vimentin, and SMA, HHF-35 by immunohistochemical staining, but negative for CD34 and S-100. Conclusion Glomus tumors are almost benign, arising from the altered smooth muscle of glomus. It can make an accurate diagnosis by integrating the clinical symptoms and location with histopathological features and immunohistochemical markers. The presence of nerve fibers and mast cells in the tumor is related to the pain. Malignant glomus tumor is rare.