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Rho激酶与支架内再狭窄 被引量：2

Rho-kinase and In-stent Restenosis
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摘要 目的支架内再狭窄与血管平滑肌分化、迁移,细胞外基质的过度增值所致新生内膜增生密切相关。Rho激酶参与支架置入引起的新生内膜增生的调节。长期抑制Rho激酶的表达可阻止新生内膜的增生,可能成为防止支架内再狭窄的一种方法 。 ISR is essentially due to vascular smooth muscle cell （ VSMC ） proliferation and migration, and exces- sive extracellular matrix production, leading to neointima foliation. Rho-kinase, a major regulator of VSMC proliferation and migration, after stenting plays its role in the neointimal formation. Long-term inhibition of Rho-kinase suppresses instent neointimal formation by multiple mechanisms. Inhibition of the Rho/Rho kinase pathway should provide a useful strat- egy to prevent ISR.
作者 王建红 李敬诚
机构地区 中国人民解放军第三军医大学附属大坪医院神经内科
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2010年第6期422-424,共3页 Chinese Journal of Arteriosclerosis
关键词 RHO激酶 支架 支架内再狭窄 Rho-kinase Stent In-stent Restenosis
分类号 R363 [医药卫生—病理学]
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参考文献23

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共引文献28

同被引文献24

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引证文献2

二级引证文献4

中国动脉硬化杂志
2010年 第6期

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