应用血清胱抑素C检测乙型肝炎后肝硬化肾功能损害

Identification renal disfunction in patients with cirrhosis using serum cystatin C

目的 探讨血清胱抑素C（Cys C）对评价乙肝后肝硬化肾小球功能损害的价值.方法 采用免疫比浊法检测182例血清样本（其中肝硬化患者及健康查体者各91例）Cys C浓度,同时以酶法检测血清尿素（Urea）及肌酐（Cr）浓度,并进行统计分析.结果 肝硬化肾小球功能损害患者血清Cys C、Urea及Cr的浓度分别为（1.20±0.42）mg/L、（6.18±2.88）mmoL/L及（70.48±22.72）μmol/L,健康对照组血清Cycs、Urea及Cr的浓度分别为（0.78±0.13）mg/L、（4.91±1.08）mmol/L及（73.47±14.31）μmol/L,肝硬化肾小球功能损害患者血清Cys C、Urea的浓度与健康对照组差异有统计学意义（t检验,P＜0.05）,Cys C检测肝硬化肾小球功能损害的阳性率为61.54%（56/91）,高于Urea及Cr,差异有统计学意义（χ2检验,P＜0.05）.结论 血清Cys C在肝硬化肾小球功能损害患者肾功能评估中具有一定的应用价值.

Objective To investigate the practical value of serum cystatin C （Cys C） for the evaluation of renal function in patients with cirrhosis. Methods One hundred and eighty two serum sample （including 91 cases of cirrhosis and 91 health individuals） were measured with partied-enhanced immunonepe lometry, which was compared with serum Urea and creatinine （Cr）. Results The concentration of serum Cys C, Urea and Cr were （ 1.20±0.42 ） mg/L, （6.18±2.88 ） mmol/L and （70.48± 22.72） μmol/L in patients with cirrhosis. The concentration of serum Cys C and Urea were higher than those in health individuals with statistics significance（ t test, P〈 0.05 ）. The serum Cys C could effectively detect renal disfunction in patients with cirrhosis, yielding a positive rate of 61.54% （56/91）, which is higher than that of serum Urea and Cr（χ^2 test, P〈0.05 ）. Conclusion The serum Cys C is a potential biomarker to evaluate renal disfunction in patients with cirrhosis.