基于环糊精的环境敏感型水凝胶的研究进展

Recent progress in the study of cyclodextrin-based environment sensitive hydrogel

介绍基于环糊精环境敏感型水凝胶及其在给药系统中的应用,为其在药剂学中的应用提供理论依据。通过查阅近年国内外文献,对基于环糊精的物理、化学和生物化学刺激敏感型水凝胶的材料分类、设计原理、作用机制及其应用特点进行详细的阐述。目前,对基于环糊精的各种环境敏感型水凝胶的研究备受关注,其感应病变部位各种环境信息的变化,实现药物控制释放。虽然迄今为止多数仍停留在实验研究阶段,但可以预见该类水凝胶在智能给药系统研究领域有着广阔的应用前景。

This is a review of recent progress in the study on environment sensitive hydrogel based on cyclodextrin and their most recent and relevant applications in the intelligent drug delivery systems. Based on relevant literatures,the development of environment sensitive hydrogel responsive to physical,chemical and biochemical stimuli was introduced,involving their categorization,design principles,mechanism of action and potential application. Various new types of intelligent drug delivery system,which responds to various triggers,could be constructed by using the cyclodextrin-based environment sensitive hydrogel. They made it possible to control the drug release freely. Although these hydrogels are still at their research stage,they have attracted considerable interest in the intelligent drug delivery system.