脑部重大疾病的基因治疗研究进展

Development of gene therapy in major brain diseases

近年来分子生物学与医学的共同发展促进了脑部疾病基因治疗的研究。本文通过查阅相关文献,进行归纳总结,综述了目前脑部重大疾病的基因治疗研究进展。针对脑部重大疾病,包括脑肿瘤、帕金森病、阿尔茨海默病及脑血管病变等的发病机制,均有较为有效的基因治疗策略。基因治疗作为脑部疾病的一种全新治疗手段,无疑对于了解脑部疾病的病因及其全面治疗具有重要意义。

In recent years, the development of molecular biology and medicine has prompted the research of gene therapy for brain diseases. In this review, we summarized the current gene therapy approaches of major brain diseases. Against the pathogenesis of major brain diseases, including brain tumors, Parkinson’s disease, Alzheimer’s disease and cerebrovascular disorders, there are several effective gene therapy strategies. It is no doubt that, gene therapy, as a novel treatment, is of great significance for understanding the causes, as well as comprehensive treatment for brain diseases.