摘要
布南色林是一种新型非典型抗精神病药物,为高度选择性的5-HT2受体和多巴胺D2受体拮抗药,对多巴胺D1受体、α1肾上腺素受体、组胺H1受体和M1胆碱受体亲和力较小。该药对精神分裂症疗效明显,不良反应小,能有效改善精神分裂症患者的阴性症状、阳性症状和认知功能。本文对该药的研究进展作一综述。
Blonanserin as a new atypical antipsychotic agent is an antagonist of serotonin 5-HT2 and dopamine D2 receptor, and displays low or very low affinities for dopamine D1, adrenergic α1, histamine H1, and muscarinic M1 receptors. Blonanserin has obvious effects on schizophrenia with fewer adverse reactions. It can improve both positive and negative symptoms of schizophrenia and some aspects of cognitive function in patients with schizophrenia. The article provides an up-to-date review of the agent.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2010年第8期571-575,共5页
Chinese Journal of New Drugs and Clinical Remedies