环氧合酶-2与重症肝炎关系的研究

Relationship between cyclooxysenase 2 and serious hepatitis

目的:观察环氧合酶-2(COX-2)与重症肝炎的关系。方法:ELISA法检测75例乙肝相关性重症肝炎患者和30例普通乙肝相关性肝病患者血清中COX-2相关前列腺素(PGs)代谢产物血栓素(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)的水平。结果:各组重症肝炎患者血清TXB2和6-ke-to-PGF1α的水平均明显高于普通肝病患者(急性重症肝炎vs正常对照,P<0.01;亚急性重症肝炎:正常对照,P<0.01;慢性重症肝炎:正常对照,P<0.01)。随着病情的转归,TXB2/6-keto-PGF1α比值明显下降。结论:TXB2、6-keto-PGF1α的水平和TXB2/6-keto-PGF1α比值对揭示肝病发生重症肝炎的发展过程有一定的实用价值,对监测病情转归和预后有重要临床意义。

AIM： To study the cytokines regulated downstream effecter cyclooxygenase（COX-2＇s） function in the progression of serious hepatitis.METHODS： Samples from 75 patients with hepatitis B virus（HBV）-associated serious liver diseases with well-characterized clinical profiles and 30 HBV-infected patients were assessed by ELISA.RESULTS： Compared with the general HBV-infected patients,serum TXB2 and 6-keto-PGF1α level were uniformly elevated in all serious hepatitis patients（acute serious hepatitis patients vs.general HBV-infected patients P0.001）;sub-acute serious hepatitis patients vs.general HBV-infected patients（P0.01）;chronic serious hepatitis patients vs.general HBV-infected patients（P0.001）.But there were no significant difference of these cytokines levels among the different types of serious hepatitis patients（P0.05）.CONCLUSION： In conclusion,product of COX-2 metabolism TXB2 and 6-keto-PGF1α were associated with the clinical progression of serious hepatitis;especially TXB2/6-keto-PGF1α ratio is an effective biological marker for prognosis and diagnosis for serious hepatitis.