期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Rho／Rho激酶信号转导通路与心力衰竭的研究进展 被引量：1

下载PDF
导出
摘要 Rho／Rho激酶信号通路的关键信号分子包括Rho蛋白、Rho激酶和肌球蛋白磷酸酶。Rho蛋白是Ras超家族中小分子G蛋白的成员之一，具有GTP酶活性。Rho．GTP在细胞的信号转导通路中作为信号转换器或分子开关，与Rho激酶的Rho蛋白结合域结合，
作者 慈新 关胜江 楚立
机构地区 河北省涿州市医院神经外科 河北医科大学基础课部
出处 《广州医学院学报》 2010年第2期102-104,共3页 Academic Journal of Guangzhou Medical College
关键词 RHO蛋白 信号转导通路 心力衰竭
分类号 R541.6 [医药卫生—心血管疾病]
  • 相关文献

参考文献14

  • 1Burridge K,Wennerberg K. Rho and Rac take center stage [J]. J Cell,2004,116(2) : 167-179.
  • 2Etienne-Manneville S, Hall A. Rho GTPases in cell biology [J]. Nature,2002,420(12) : 629-635.
  • 3Amano M, ho M, Kimura K, et al. Phosphorylation and activation of myosin by Rho-associated kinase (Rhokinase) [J]. J Biol Chem,1996,271 (34) :20246-20249.
  • 4Koyama M, Ito M, Feng J,et al. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosinphos phatase, by Rho kinase [ J ]. FEBSLett, 2000,475 ( 2 ) : 197- 200.
  • 5Kitazawa T, Eto M, Woodsome TP, et al. Phosphorylation of the myosinphosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle [ J ]. J Physiol, 2003,546 ( 3 ) : 879-889.
  • 6Indolfi C, Di Lorenzo E, Perrino C, et al. Hydroxymethylglutaryl coenzyme a reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21 ras activation, Circulation [ J ], 2002, 106 (16) :2118-2124.
  • 7Morissette MR, Sah VP, Glembotski CC, et al. The Rho effector, PKN, regulates ANF gene transcription in cardiomyocytes through a serum response element [ J ]. Am J Physiol Heart Circ Physiol,2000,278(6) : 1769-1774.
  • 8Satoh S, Ueda Y, Koyanagi M, et al. Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension- induced heart failure [ J ]. J Mol Cell Cardiol, 2003,35 ( 1 ) :59-70.
  • 9Kaibuchi K, Kuroda S, Amano M. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells [ J ]. Annu Hey Siochem, 1999,68 (2) : 459-486.
  • 10Suematsu N, Satoh S, Kinugawa S, et al. Alphal- adrenoceptor-Gq-RhoA signaling is upregulated to increase myofibrillar Ca2+ sensitivity in failing hearts [J]. Am J Physiol Heart Circ Physiol,2001,281 (2) : 637-646.

二级参考文献33

  • 1罗洁,闵苏.新型脑、心血管活性药——法舒地尔[J].中国新药与临床杂志,2006,25(12):941-945. 被引量：47
  • 2Lips D J, deWindt LJ, van Kraaij D J, et al. Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy [J]. Eur Heart J, 2003 ; 24 ( 10 ) : 883-96.
  • 3Loirand G, Guerin P, Pacaud P. Rho kinases in cardiovascular physiology and pathophysiology[J]. Circ Res,2006 ;98 (3) :322-34.
  • 4Hattori T, Shimokawa H, Higashi M, et al. Long-term inhibition of Rho-kinase suppresses left ventrieular remodeling after myocardial infarction in mice[J]. Circulation,2004 ; 109 ( 18 ) :2234-9.
  • 5Mukai Y, Shimokawa H, Matoba T, et al. Involvement of Rho-kinase in hypertensive vascular disease : a novel therapeutic target in hypertension [J]. FASEB J,2001 ;15 (6) :1062-4.
  • 6Phrommintikul A,Tran L, Kompa A, et al. Effects of a rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction[J]. Am J Physiol Heart Circ Physiol,2008 ;294 (4) :H1804- 14.
  • 7Higashi M, Shimokawa H, Hattori T, et al. Long-term inhibition of Rho-kinase suppresses angiotensin Ⅱ-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD (P)H oxidase system [J]. Circ Res, 2003 ;93 (8) :767-75.
  • 8Yamazaki T, Komuro I, Zou Y ,et al. Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both α1 and β-adrenoceptors [J]. Circulation, 1997 ; 95 ( 5 ) : 1260 -8.
  • 9Ocaranza MP, Diaz-Araya G, Chiong M, et al. Isoproterenol and angiotensin Ⅰ-converting enzyme in lung,left ventricle,and plasma during myocardial hypertrophy and fibrosis[J]. J Cardiovasc Pharmacol,2002 ;40 (2) : 246-54.
  • 10Takemoto Y, Yoshiyama M, Takeuchi K, et al. Increased JNK, AP-1 and NF-kappa B DNA binding activities in isoproterenol-induced cardiac remodeling[J]. J Mol Cell Cardiol,1999 ;31 (11) :2017-30.

共引文献4

同被引文献14

引证文献1

二级引证文献28

广州医学院学报
2010年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部