乳腺癌病人血浆肿瘤型M2丙酮酸激酶的表达及临床意义探讨

The Expression and Significance of Tumor Type M2 Pyruvate Kinase in Serum of Patients with Breast Cancer

目的研究乳腺癌患者手术前后外周静脉血№丙酮酸激酶（M2-PK）水平的变化及其临床意义。方法用酶联免疫吸附法（ELISA）对40例乳腺癌患者手术前后、40例乳腺良性病变及50例健康体检者空腹外周静脉血中M2-PK的含量进行检测并分析比较。结果①乳腺癌患者术前血浆M2．PK的水平较乳腺良性病变组及健康对照组显著增高（P〈0．01）。②乳腺癌TNMⅢ、Ⅳ期病人血浆M2．PK的水平显著高于Ⅰ、Ⅱ期患者（P〈0．05）。③乳腺癌根治术后血浆M2-PK的水平较术前显著降低（P〈0．01）。结论血浆肿瘤型M2-PK水平的检测对乳腺癌的筛选、预后及术后复发的判断有重要价值。

Objective To investigate the clinical significance of variation of plasma level of tumor M2-PK in breast carcinoma patients before and after operation. Methods The plasma level of tumor M2-PK was measured by ELISA in forty patients with breast carcino- ma before and after operation, forty patients with breast benign lesion and fifty heahhy persons. Results ①The preoperative M2-PK level in patients with breast carcinoma were significantly higher than those in patients with breast benign lesion and in healthy controls（ P 〈 0.05 ）. ② M2-PK level in patients with breast carcinoma in the stage Ⅲ and stage Ⅳ was significantly higher than those in the stage Ⅰ and stage Ⅱ （P 〈 0.05 ）. The postoperative M2-PK level in patients with breast carcinoma was significantly lower than the preoperative level （ P 〈 0.05 ）. Conclusion It suggested that tumor M2-PK can be used to screening and prognosis for breast carcinoma.