肿瘤坏死因子-α及白介素在急性胰腺炎中的作用

Effect of Tumor Necrosis Factor-α and Interleukin in Acute Pancreatitis

目的总结急性胰腺炎(AP)时细胞因子网络的变化,各细胞因子的分类、相互作用及对全身的影响。方法复习近年来国内、外有关AP时细胞因子方面的文献并进行综述。结果 AP时细胞因子网络变化复杂,互相影响,存在各种调节机理。其中肿瘤坏死因子-α(TNF-α)及白介素类细胞因子在AP进展中起着重要作用。结论 AP时细胞因子的变化是一个复杂的过程,单独调节某个因子的释放对于治疗疾病本身并无明显效果,从免疫平衡角度考虑治疗应该是较好的研究方向。

Objective To summarize the change in the cytokine network,the classification of various cytokines,interaction,and systemic impact on patients with acute pancreatitis （AP）. Methods The recently published literatures in domestic and abroad about advancement of cytokines in AP were reviewed. Results Cytokines had a complex network and interactions. There were a variety of regulatory mechanisms. The tumor necrosis factor-α （TNF-α） and interleukin cytokines played important roles in the progress of AP. Conclusions Change of cytokines during AP is a complex process. Any separate regulation for the release of sigle factor has no significant effect on the disease. The treatment according to immune balance should be a better direction.