摘要
目的探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者血浆内皮素-1(endothelin-1,NET-1)及内皮素受体B(endothelin receptor B,EDNRB)含量变化与COPD发生的关系;这两项指标之间的相关性以及吸烟是否会影响血浆中ET-1及EDNRB的浓度发生变化。方法采用ELISA法测定血浆ET-1、EDNRB的含量。结果 COPD患者急性加重期血浆中ET-1和EDNRB的浓度明显高于健康对照组(P<0.05),ET-1与EDNRB含量经统计学处理呈正相关(r=0.284,P<0.05)。吸烟与非吸烟组ET-1和EDNRB血浆含量的变化无统计学差异(P>0.05)。结论 ET-1、EDNRB是参与COPD急性期发病过程的重要因素。
Objective To study the plasma levels of endothelin-1 （ET-1） and endothelin receptor B （EDNRB） in patients with chronic obstructive pulmonary disease （COPD）. To investigate whether smoking will lead alterations of ET-1 and EDNRB. Methods ET-1 and EDNRB in plasma were measured by ELISA. Results Patients with acute exacerbation of COPD demonstrated higher plasma levels of ET-1 and EDNRB than healthy subjects （ P 〈 0.05 ）. The changes of plasma ET-1 were positively correlated with EDNRB （r = 0.284 ,P 〈 0.05 ）. Smoking did not lead to significant alterations in ET-1 and EDNRB. Conclusion ET-1 and EDNRB are likely involved in acute phase of COPD.
出处
《同济大学学报（医学版）》
CAS
2010年第4期79-81,共3页
Journal of Tongji University(Medical Science)
关键词
慢性阻塞性肺疾病
内皮素-1
内皮素受体B
chronic obstructive pulmonary disease
endothelin-1
endothelin receptor B
